pipette

专利摘要:
invention patent: dosing device and dosing process. the present invention relates to a dosing device (10; 10b) comprising a conductive tube 20,20a, 20b, a piston 24,24a, 24b, which is movable in the conductive tube 20,20a, 20b, an activation set 40,40a , 42 to exert a force on the piston 24,24a, 24b in order to move the piston 24,24a, 242b inside the conductive tube 20,20a20b and a chamber 28,30 to receive a product 34 to be dosed, the product 34 to be dosed according to piston displacement 24.24a, 24b can be aspirated or released, and the activation set 40.40a, 42 is configured for changing magnetic effect with piston 24.24a, 24b.
公开号:BR112012016438B1
申请号:R112012016438
申请日:2011-01-05
公开日:2020-05-05
发明作者:Hofstetter Meinrad；Kirste Vinzenz
申请人:Hamilton Bonaduz Ag；
IPC主号:

专利说明:

Invention Patent Descriptive Report for PIPETA. Description [0001] The present invention relates to a pipette, comprising a conductive tube, an integrated piston movable within the conductive tube and a chamber for receiving a medium to be dosed, the medium to be dosed may be aspirated or released , according to a piston displacement. In addition, the invention covers a dosing process, using a pipette of this kind.
[0002] The dosing devices of this species, for example, pipettes with a vitreous tube, are inserted in one of whose ends a displaceable piston is inserted, and in whose other end is a nozzle, through which the medium to be dosed - of according to piston displacement - can be aspirated or released. Between the piston and the medium to be dosed, a liquid or gaseous displacement medium can also be provided, so that the medium to be dosed can also be completely expelled from the chamber, in other words, the smallest possible quantities can also be aspirated.
[0003] Activation assemblies are known for activating the piston inside the conductive tube, which are coupled with the piston and, for example, transform a rotating movement of a regulating element into a displacement movement of the piston. The rotating movement of the regulating element can, in this case, be carried out manually or using an electric motor, being that a certain angular extension of the rotation, that is, a certain number of rotations of the regulating element, is transformed in a determined path. of displacement of the piston and, with this, it is transformed into a determined volume (dose) aspirated or released from the medium to be dosed.
[0004] For some uses, especially in the laboratory, precise dosing is important, that is, dimensioning
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2/35 exact amount of product aspirated or released. By means of relatively complex mechanical gearboxes, and with the use of precision electric motors, the known metering devices aim at the most accurate possible positioning of the piston, as well as the most uniform possible movement of the piston. In this case, comparatively high positioning accuracy can be achieved with a relatively high positioning accuracy, however, to the same extent, the dynamics of the dosing process is impaired, since gearboxes operate only with great inertia. In addition, these gears are expensive and require intensive maintenance. The drive by means of electric motors also generally requires the use of gear gears and the accuracy is impaired, due to the clearance of the motor in the direct activation of the engine piston.
[0005] Another known problem with conventional metering devices is the precise adjustment, which is necessary between the piston and the conductive tube, so that, on the one hand, the piston is sufficiently sealed in relation to the conductive tube, in order to prevent flow of medium to be dosed, that is, displacement product, or the penetration of air, and, on the other hand, the piston is not positioned too fixed inside the conductive tube, in order to reliably enable a displacement of the piston in a certain travel distance.
[0006] Based on these fundamentals, it is the objective of the present invention to offer a pipette of the species initially mentioned, as well as a dosing process, using a pipette of this species, with which a medium to be dosed can be aspirated or released with greater precision and dosage, and that, preferably, it can be carried out in a simple way and at an advantageous cost.
[0007] According to a first aspect of the invention, this task is
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3/35 solved by a pipette, comprising a conductive tube, an integrated piston movable in the conductive tube, an activation set to exert a force on the piston in order to move the piston inside the conductive tube, and a chamber to receive a medium to be dosed, and the medium to be dosed, according to a displacement of the piston, can be aspirated or released and, according to the invention, that is, activation set, is prepared for a changing magnetic action with the piston.
[0008] An important aspect of the invention, therefore, lies in the activation of the piston by magnetic interaction. This means that a force to move the piston inside the conductor tube is a magnetic force, based on a magnetic field. Contrary to conventional metering devices, therefore, there is a movement of the piston not by mechanical transfer of force between a regulating element and the piston, but by magnetic interaction, free from contact. The missing mechanical coupling between the activation set and the piston eliminates sources of failures that were unavoidable in conventional metering devices, based on a clearance of the activating gear or the motor or due to friction. Thus, the pipette according to the invention - for the case in which the magnetic field is generated and altered by means of a magnetic field generator set, moved by a gearbox prevents, as far as possible, a transfer of vibrations, conditioned to gear shocks, resulting from play, and so on, on the piston. Correspondingly, a dosing device according to the invention allows the aspiration or release of a medium to be dosed with particularly high dosing accuracy.
[0009] In addition, the movement of the piston through magnetic force allows intense dosing dynamics. If, during
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4/35 dosing process, the magnetic field is readjusted with electrical or electronic means, for example, by switching coils, then a piston movement can take place with very little delay.
[00010] Basically, the piston itself could generate a magnetic field, for example, it could present a permanent magnet, so that it can enter a changing effect with an element of the magnetic or magnetizable activator set (especially ferromagnetic) and by the movement of the element magnetic or magnetizable of the activation set, it could produce a displacement of the piston in relation to the conductive tube. In view of the activation of the magnetic field for the dosage of the product, it is, however, considered advantageous that the activation set has a set to generate a magnetic field. In this way, means for generating and activating the magnetic field can be arranged outside the conducting tube, at an effective magnetic distance.
[00011] For changing effect with the magnetic field generator set, it is preferred that the piston - at least in segments - be formed of a permanent magnetizable or magnetic material. The magnetizable material preferably comprises a ferromagnetic material. However, this expression also includes paramagnetic, diamagnetic or ferromagnetic superconducting materials, provided that in the magnetic field they present a sufficient degree of magnetisability to exert a significant force on the piston to move within the conductive tube.
[00012] In another preferred embodiment, the piston may be formed from a magnetizable liquid, preferably from a ferrous fluid. This mode allows the piston to move with special intense dynamics, due to the particularly reduced frictional forces between the piston and the conductive tube. In addition, the ferrous fluid seals, in a
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5/35 naturally and reliably in relation to the conductive tube, so that reliable operation of the metering device can be ensured with simple means. In the magnetic field, the magnetizable liquid has the tendency to remain in the area of greatest intensity of magnetic field, so that the magnetizable liquid, on the one hand, remains distributed within the conductive tube, exercising a reliable seal, and, on the other hand, corresponding to the external magnetic field, it can be moved inside the conductor tube.
[00013] Preferably, the magnetic field generator set of a pipette according to the invention generates a magnetic field, the magnetic flux of which passes through the piston essentially axially towards the conductive tube. With such an orientation of the magnetic flux, the shifting effect between magnetic field and piston is aligned in the direction of the piston displacement, so that the force effect on the piston can act efficiently in the direction of the piston displacement. In order that, finally, a piston movement can be achieved to measure the product, a change in the size, orientation or position of the magnetic field is necessary. In the simplest case, this can be achieved by activating or deactivating the magnetic field, so that the piston, for example, during a certain period, is attracted or repelled by the magnet and, thus, will be displaced in a certain stretch. Alternatively or additionally, by moving the magnetic field generator set, the magnetic field can be moved relative to the conductive tube, so that the piston follows this movement. As another alternative or additional possibility, the direction or intensity of the magnetic flux of the magnetic field could be altered or a deformation of the magnetic field could be made by local change of direction and intensity of the magnetic flux, correspondingly with that.
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6/35 change the magnetic forces acting on the piston, resulting in displacement of the piston (for example, in an arrangement with several magnets and / or coils by command / movement of individual magnets / coils).
[00014] In an especially simple modality, the magnetic field generating field may include a permanent annular magnet, which surrounds the conductive tube coaxially. To move the piston, the permanent magnet can be moved in the axial direction of the conductive tube, with the piston especially endeavoring to be positioned in the center of the permanent ring magnet. Alternatively, the permanent magnet could also present such a magnetization that the piston is repelled by it.
[00015] In another preferred embodiment, it is provided that the magnetic field generator set comprises a set of coils with at least one coil, whose spirals coaxially surround the conductor tube. By command of the intensity of the current supplied, such coil may form an alterable magnetic field in order to attract the piston, with adjustable force, towards its axial center. The coil can be moved alternatively or additionally, in a coaxial direction, in relation to the conductive tube, in order to move the piston.
[00016] Special possibilities for flexible and accurate dosing result in a modality, in which the magnetic field generator set comprises a set of coils with a variety of coils, whose spirals coaxially surround the conductor tube, the coils being axially offset from one another . By regulating the intensity of currents fed to the different coils, the magnetic field within the conductor tube can be changed in relation to its overall intensity, as well as its axial flow distribution, in order to pull the piston to a position defined inside the conductor tube. In simple case,
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7/35 two coils may be alternately operated, arranged axially at a distance, in order to move the piston in shuttle between two positions.
[00017] A set of coils with a variety of coils, according to the present invention, can also be considered a set similar to an autotransformer that covers a coil through winding, with terminal contacts, as well as a central contact, so that the two coil segments can be activated individually between the terminal contacts and the central contact. In another variant of such a coil set, the central contact may be displaceable along the coil axis between the terminal terminals, in order to change the ratio of the number of spirals of the two coil segments.
[00018] The specialist must know a variety of other possibilities to generate a magnetic field and integrate the piston of the dosing device according to the invention within the magnetic field, and by changing the magnetic field, that is, by the movement of other elements of the metering device, produce a desired displacement of the piston within the conductive tube.
[00019] Preferably, the dosing device of the invention also comprises a control set for controlling the intensity and / or position or / and the direction of the magnetic field, so that the movement of the piston and the position of the piston within the tube driver are controllable. An electronic control set allows for reliable, fast and precise movement and positioning and, if desired, also adjustment of the piston position by recording a pickup value, movement indicator or piston position, for example, from a pressure detector. position or a scale that records the amount of product aspirated or released.
[00020] According to a second aspect of the invention, the task
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8/35 of the invention is solved by a pipette, comprising a conductive tube, an integrated movable piston inside the conductive tube and a chamber to receive a medium to be dosed, the medium to be dosed - according to a displacement of the piston - can be aspirated or released, and, according to the invention, between the piston and the conductive tube, a sliding film of a magnetizable liquid is provided and the dosing device comprises a magnetic field generator set to generate a magnetic field, acting on the sliding film. A striking feature of the second aspect of the invention is, therefore, the use of a magnetizable material within the scope of the dosing device piston, so that, by the changing magnetic action, it reinforces a movement of the piston for dosing the product. According to the second aspect of the invention, the magnetic field of a magnetic field generator assembly causes the sliding film, formed of magnetizable liquid, to remain reliably in the intermediate compartment between piston and conductive tube. On the one hand, this has the advantage of making possible a movement with reduced piston friction index, with intense dynamics. On the other hand, depending on the second aspect of the invention, an essentially greater seal of the chamber can be achieved against the environment of the dosing device.
[00021] Especially preferably, in a pipette of the invention, characteristics of the first aspect and characteristics of the second aspect of the invention are reciprocally combined, that is, the magnetic field provides not only a stable sliding film of a magnetizable liquid between piston and conductive tube , however, at the same time it moves the piston inside the conductive tube to measure the product. In this case, the fact that an escape from the sliding film can be avoided with special safety is taken advantage of
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9/35 when the sliding film is in place of the piston, following the movement of the piston within the magnetic field.
[00022] In order to be able to reliably predetermine the axial position of the sliding film, the magnetic field generator set should preferably be prepared to generate a magnetic field, whose magnetic flux, at the piston location, is essentially aligned in the direction axial to the conductive tube. If this modality is also combined with characteristics of the first aspect of the invention, then, simultaneously, the position of the piston within the magnetic field can be reliably matched, since the direction of displacement of the piston essentially coincides with the direction of the magnetic field.
[00023] According to a third aspect of the invention, the task of the invention is solved by a product dosing process, using a dosing device, especially a dosing device according to the first or / and second aspect of the invention , the dosing device comprising a conductive tube, a piston movably inserted into the conductive tube, as well as a chamber to receive the medium to be dosed, the medium to be dosed - corresponding to a displacement of the piston - will be aspirated / released and the dosing process includes the following steps: Providing a magnetic field and exerting a force on the piston by magnetic interaction of the piston with the magnetic field. Also with a dosing process of this kind, a simple and precise dosage with intense dynamics can be achieved, and essentially, without mechanical coupling, a magnetic force is exerted on the piston resulting from a changing action of the piston with a magnetic field. By changing the position, direction or intensity of the magnetic field, or by the deformation of the magnetic field, a
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10/35 movement of the piston inside the conductive tube for the purpose of dosing the product.
[00024] The dosing process may preferably be carried out using a dosing device depending on the modalities of the first and / or second aspects of the invention, in order to achieve the effects and advantages described for the respective modalities of the first, that is, according to the aspect of the invention.
[00025] When the dosing process is carried out with a metering device that covers a set of coils with a variety of coils, whose spirals coaxially surround the conductor tube, the coils being axially offset from one another, with the current intensities being fed to the coils can be controlled according to the determination of a dose to be aspirated or released, so that, with electronic means, precisely a desired amount of medium to be dosed can be aspirated or released. [00026] According to a fourth aspect of the invention, the underlying task of the invention is solved by a dosing device, comprising a conductive tube, an integrated piston movable in the conductive tube, an activation set to exert a force on the piston in order to to move the piston inside the conductive tube, as well as a chamber to receive a medium to be dosed, the medium to be dosed can be aspirated or released in a way corresponding to a displacement of the piston, and the activation set is prepared for a magnetic interaction with the piston and the piston has a permanent magnet. The permanent piston magnet of the fourth aspect of the invention preserves - even without continuous power supply - a definite magnetization that can be used to position or move the piston through the activation set. The use of a permanent magnet therefore makes it possible to reduce the energy required for the operation of the
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11/35 dosing device.
[00027] Preferably, the pipette piston of the fourth aspect comprises at least two adjacent segments of the permanent magnet, whose magnetizations extend axially towards the conductive tube, and the magnetizations of adjacent permanent magnet segments are positioned in the opposite direction. In such an arrangement, at the points where the direction of the magnetizations changes, that is, in the area of the transition of segments adjacent to the permanent magnet, relatively intense magnetic fields are generated, with radial projection, which enable an especially precise positioning and high local resolution of the position axial piston. This gain in accuracy, which is expressed by the greater accuracy of the dosing device, can be attributed to the greater relative external change of the magnetic field with axial displacement of the piston.
[00028] Although the aforementioned effect has already been achieved in the provision of only two adjacent permanent magnet segments, with magnetizations in the opposite reciprocal direction, according to a preferred embodiment of the invention as the fourth aspect is provided to dispose in the axial direction of the conductive tube more than that two permanent magnet segments, with adjacent permanent magnet segments always showing opposing magnetizations. As each permanent magnet segment can be understood in such a way that, at one of its axial ends, it presents a magnetizable north pole, and at its other axial end, it presents a magnetic south pole, the arrangement of the permanent magnet powder segments, with changing magnetization direction, according to a fourth aspect of the invention can also be described in such a way that adjacent segments of permanent magnet are either facing their south poles or always with
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12/35 their north poles, are facing each other. This effect of a magnetic field that protrudes with special intensity and characteristics in a radial direction is then present precisely in the transition areas in which the north poles, that is, the south poles of the adjacent permanent magnet segment, meet reciprocally.
[00029] According to a particularly simple embodiment of the invention of the fourth aspect, it is provided that the permanent magnet segments formed by permanent magnets that are so reciprocally attached that the north magnetic poles of adjacent permanent magnets are arranged facing each other or adjacent and, respectively, adjacent permanent magnet magnetic south poles facing each other, being arranged adjacent. A piston formed in this way can be produced in a particularly simple manner from a variety of known permanent magnet cylinders, which are attached adjacent in a changing orientation, preferably being glued together. A piston according to the fourth aspect of the invention could, alternatively, however, also be achieved also by the magnetization of a ferromagnetic material, through the action of a correspondingly constituted magnetic field.
[00030] In another embodiment of the invention, it is provided that the piston comprises at least one sealing body, which is disposed between an inner wall of the conductive tube and the segments of the permanent magnet or permanent magnets. In this way, the advantage will be that the piston permanent magnet specifically does not have to be manufactured absolutely with precise adjustment, corresponding to the internal dimensions of the conductor tube, and a reliable seal between the permanent magnet and the conductor tube can be ensured. In this case, it is especially taken into account that at least one sealing body is
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13/35 shaped like a lid, being positioned on an upper axial end or / and on an inner axial end of the permanent magnet or is applied to a segment of the highest axial and / or lower axial permanent magnet. In this way, the cap-shaped sealing bodies can be placed in such a way on the ends of the permanent magnet body that surround the circumferential end segments, as well as the front end faces of the permanent magnet body, and contact between the medium can be avoided. to be dosed and the permanent magnet body.
[00031] The invention according to the fourth aspect, solves the task of the invention in an independent and object-specific way from the inventive aspects of one to three. Preferably, the characteristics of the dosing device of the fourth aspect, however, are combined with one or more characteristics of the aspects from one to three, in order to obtain the advantages and achievements indicated in connection with aspects one to three.
[00032] According to one embodiment of the present invention, depending on one or more of the aspects described above from one to four, it is provided that the activation device has a magnetic field generator set to generate a magnetic field, the generator set being magnetic field has an array of coils with at least one coil, which has at least one spiral, with at least one spiral surrounding only a partial segment of the circumference of the conductive tube.
[00033] In this modality, at least one bend of the coil surrounds the conductor tube not completely, that is, it is not completely wrapped (at a 360 degree circumferential angle) around the conductor tube, but it surrounds only a partial segment of the circumference of the conductive tube (at a surrounding angle of less than 360 degrees), so that another partial segment of the circumference
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14/35 of the conductor tube is free from the spiral. In this case, the conductive tube still offers access in a circumferential segment not yet covered by the spiral, for example, to enable visual control of the dosing process or to provide a position recording element in the conductive tube to register a piston position or movement. Depending on the size of the partial segment, not covered by the spiral, and depending on the spiral path, advantages can also be created with regard to the arrangement, especially the density of the arrangement of several adjacent pipettes or the arrangement of adjacent coils, as the case may be. later it will be described in more detail.
[00034] A similar application as the modality described above, follows another advantageous modality of the invention, according to one of the aspects from one to four, in which the activation set has a magnetic field generator set to generate a magnetic field, the magnetic field generator set comprises a set of coils with at least one coil, which has at least one spiral, at least this single spiral extending completely on one side of a longitudinal central plane containing a longitudinal central axis conductor tube. In this way, it is possible to achieve that the coil essentially requires only half of the existing construction space around the conductor tube, while the other half offers full access, for example, always for a second identical coil, for a position recording element or also for an adjacent juxtaposition of several pipettes.
[00035] Especially it is considered, in this case, that the set of coils involves a first coil with at least one first spiral, and a second coil with at least one second spiral, with at least the first single spiral projecting completely in one side of the longitudinal central plane and at least the second spiral protrudes entirely along the longitudinal central plane. By
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15/35 coils applied to the TC from opposite sides, an especially uniform and definable axial magnetic field may be generated inside the conductor tube, preferably in the region of the longitudinal central plane, a partial segment of the circumference of the hand conductor tube is still covered by neither a spiral of the first coil nor a spiral of the second coil, thus allowing access to the conductive tube, for example, for a position recording element or for visual control of the dosing process.
[00036] In a preferred variant of the two modalities described last, it is envisaged that at least one coil spiral extends entirely between two tangential planes of the reciprocally parallel conductor tube that touch the outer wall of the conductor tube. In this variant, especially in the juxtaposition of several conducting tubes, more joint density can be achieved, since adjacent conducting tubes can be arranged at a relatively reduced reciprocal distance. While especially a variety of coils that completely surround the conductor tube quickly results in increased space requirements, the minimum distance between two adjacent conductor tubes - using a coil set according to this variant of the invention - will not be determined by the steel thickness least one coil spiral. Instead, a row of adjacent conductive tubes, according to this variant of the invention, can be placed in such an adjacent direction that the tangential planes, described above, of adjacent conductive tubes project, essentially, in a reciprocal parallel direction. The conductive tubes can then be arranged so densely that the outer walls of adjacent conductive tubes touch or almost touch.
[00037] Preferably, a segment of the spiral that shows only a partial segment of the circumference of the conductive tube if
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16/35 extends along an external wall of the conductive tube, in the circumferential direction of this conductive tube. Such a spiral segment can generate a magnetic field inside the conductive tube that projects in an axial direction, and that can come into contact with the piston. [00038] In addition, a segment of at least one spiral can extend axially along an external wall of the conductive tube. An axial spiral segment is preferably connected within the same spiral with a spiral segment, described above, which extends in a circumferential direction, so that the magnetic field, generated by the axial spiral segments, develops a changing effect smaller with the piston and the axial segment of the preferred spiral serves to add and remove current to / from the spiral segment that projects circumferentially.
[00039] An especially advantageous combination of the spiral segment extending circumferentially, as well as the axial segment of the spiral, results together with the fourth aspect of the invention described above, in which the piston has at least one permanent magnet, especially a variety of adjacent permanent magnet segments with changing magnetizing directions. Advantageously, the axial length of the axial projection permanent magnet segment can be adjusted to a segment length of the permanent magnet or of the permanent magnet itself.
[00040] In another variant of the invention, it is envisaged that at least one spiral wrapping only in a partial segment of the circumference of the conductive tube presents a spiral segment that extends in the direction of the conductive tube, and then extends along the conductor tube and then moves away from the conductor tube. In this variant, parts of the spiral that cannot contribute to producing the desired magnetic field at the piston location, can be conducted at a distance from the conductor tube, so that its magnetic field does not
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17/35 impairs the magnetic field of the active components of the spiral that extend along the conductive tube. Thus, a very definable and relatively homogeneous magnetic field can be formed inside the conductor tube although at least one spiral - contrary to the case of a normal coil spiral - does not completely surround the conductor tube. [00041] As already indicated, in the partial segment of the circumference of the conductive tube that does not involve at least one spiral, a position recording element may be designated. This position recording element can be part of a position detector, which - through the position recording element - captures a pickup value that indicates the movement or position of the piston. This pickup value can be used especially for position adjustment, already mentioned with the first aspect of the invention, and a control set regulates the piston position by integrating the pickup value. In this way, very precise and automatic dosing is possible.
[00042] The position recording element can also be prepared for a magnetic shifting effect with the piston, that is, it can determine a position or / and movement of the piston, especially by recording a magnetic field generated by the piston. The magnetic field generated by the piston can then simultaneously be used both for the control of the piston (transfer of force to the piston) as well as for recording the position / movement of the piston, resulting in a simplified constitution.
[00043] Next, the invention will be explained on the basis of preferred examples of execution, with reference to the accompanying drawings. The figures show:
figure 1 - sectional view of a pipette according to a first example of execution of the invention, including a cut-out magnification,
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18/35 figure 2 - a cross-sectional view of a pipette according to a second embodiment of the invention, including a cut-out magnification, figure 3 - a schematic side view of a pipette according to a third embodiment of the invention, figure 4 - a side view of a pipette according to a third example of execution of the invention, figures 5 to 5c - presentations for magnetizing a permanent magnet body of a pipette piston, shown in figure 4, figure 6 - a presentation on the path of magnetic field lines of the permanent magnet body shown in figures 5a through 5c, figure 7 - perspective view of a pipette cutout according to a fourth example of the invention, figure 8 - perspective view of a segment of a pipette according to a fifth example of implementation of the invention, figure 9 - sectional view of the pipette shown in figure 4 in normal Axial section plane, and figure 10 - a transverse view of the pipette, most shown in figure 7, in a normal axial section plane.
[00044] A pipette 10 of the first execution example, shown in figure 1, comprises a cylindrical conductive tube 20 of vitreous material, in which open upper end 22 is displaced, a piston 24, in whose lower end 26 opposite is fitted a nozzle segment 28.
[00045] The interior of the nozzle segment 28, as well as the interior of the conductive tube 20 between the piston 24 and the nozzle segment 28, forms a chamber 30, which, in the execution example, is partially filled with a product of displacement 32 and, elsewhere, is full of
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19/35 a product 34 to be pipetted. The displacement product 32 is adjacent to the piston 24, while the product to be pipetted is adjacent in a nozzle opening 36 nozzle segment 28.
[00046] A movement of the piston 24 in an axial direction of the conductive tube 20, that is, along a longitudinal central axis A of the conductive tube, produces a change in the volume of the chamber 30 and, correspondingly, an expulsion (dispersion, ie , release) of product to be pipetted from the opening of the nozzle 36, or produces an aspiration of product 34 to be pipetted through the opening of the nozzle 36 in the chamber 30.
[00047] At least in segments, piston 24 is formed of magnetizable material and in the execution example it is produced entirely of ferromagnetic metal. Between the outer circumference of the piston 24 and the inner wall of the conductive tube 20, a sliding film 38 of a ferrous fluid is provided, so that the film of the ferrous fluid 38 surrounds the piston 24 integrally, making the seal for all sides, in the direction of the conductive tube. The sliding film 38 thus serves both for sealing and for driving, with little friction, the piston 24 within the conductive tube 20.
[00048] The conductive tube 20 is conducted concentrically through a permanent magnet 40. The permanent magnet 40 is so magnetized that its north pole 40N magnetic and its south pole 40S magnetic are mutually offset in axial direction. In the execution example, the north pole 40N faces the nozzle segment 28, and the south pole 40S faces the open end 22 of the conductive tube 20. Naturally, the ring may be engaged in another orientation in the conductive tube 20 , so that its magnetic south pole 40S faces the nozzle segment 28.
[00049] The permanent magnetic ring 40 generates at its center, that is,
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20/35 at the location of the piston 24, a magnetic field approximately homogeneous, whose field lines extend parallel to the longitudinal central axis A. The ferromagnetic material of the piston 24 is magnetized by the magnetic field. Between the magnetized piston 24 and the magnetic field of the permanent magnetic ring 40, then a monomeric magnetic interaction is felt in the sense of an attractive force between the piston 24 and the permanent magnetic ring 40.
[00050] Correspondingly, piston 24 always strives to be positioned in the center of permanent magnet ring 40. If permanent magnet ring 40 is moved axially to the conductive tube 20, then piston 24 follows this movement and sucks, that is, it correspondingly releases the product 34 to be pipetted through the opening of the nozzle 36.
[00051] The permanent magnetic ring 40 can be moved manually or by means of appropriate movement control means, in an automatic way, and the movement by means of an electronic control set - in a manner well known to the specialist - can be activated , controlled or regulated. Regardless of the mode and form of movement of the permanent magnetic ring 40, there is a transfer of movement from the permanent magnetic ring 40 to piston 24 free of contact, exclusively by magnetic interaction, so that vibrations, cohes resulting from gaps, mechanical inaccuracies and similar occurrences, can be decoupled from piston 24 and from the conductive tube 20, thus making it possible to have a very accurate dosage. With decoupling, contamination of the activator assembly and, possibly, of the control assembly per product to be pipetted or vice versa, impurities from the ready to be pipetted for example by means of lubricants from a permanent magnet movement set 40.
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21/35 [00052] In addition, the permanent magnetic ring 40 can be moved at high speed in order to achieve a high dynamic dosage. In this case, the sliding film 38 reinforces a quick movement of the piston 24 with reduced frictional losses. The sliding film 38, formed of ferrous fluid, will also be magnetized in the magnetic field of the permanent magnetic ring and, therefore, magnetic interaction with the external magnetic field is also established. By the attraction force thus caused between the sliding film 38 and the permanent magnetic ring 40, the sliding film 38 will be reliably maintained together with the piston 24 at the same axial height with the permanent magnetic ring 40, so that the sliding film 38 always remains in the intermediate space between the piston 24 and the inner wall of the conductive tube 20.
[00053] Next, with reference to figure 2, a second example of carrying out the invention will be explained. Identical or corresponding elements of the second example of execution are designated, in comparison with the first example of execution, with the same reference number, supplemented by the suffix “a” and then explained only in relation to their differences with the first example of execution, and furthermore, reference is made to the description of the first example of execution.
[00054] The pipette 10a of the second execution example comprises a conductive tube 20a with a piston 24a there integrally displaceable, which is formed entirely of a magnetizable liquid, especially of a ferrous fluid.
[00055] According to the first execution example, also in the second execution example, the conductive tube 20a of the pipette 20a is guided coaxially through a permanent magnetic ring 40a, so that the piston 24a is disposed in the magnetic field of the
Petition 870190027151, of 03/21/2019, p. 24/46
22/35 permanent magnetic ring 40a. The magnetic field performs two functions in the second example of execution. Firstly, it prevents the flow of the ferrous fluid, since the ferrous fluid always has a tendency to remain in the area of the highest magnetic field strength, that is, it is pulled into the center of the permanent magnetic ring 40a and, therefore, seals surely the conductive tube 20a on its internal wall, or its entire circumference. Second, by a movement of the magnetic field, especially by displacing the permanent magnetic ring 40 a, in the axial direction of the conductive tube 20a, the piston 24a of the ferrous fluid can be displaced along the longitudinal central axis A of the conductive tube 20a in order to aspirate, that is, release, a determined quantity of product to be pipetted, according to the displacement path. Pipetting can take place as in the first example of execution - with a very intense dynamics, since the ferrous fluid slides with little friction in the conductive tube 20a.
[00056] In the first, as well as in the second execution example, the magnetic field is generated by a permanent magnetic ring 40, that is, 40a. Generally, according to embodiments of the invention, the magnetic field can be arranged in many ways, especially in the form of an electromagnet. An example of an arrangement in which the magnetic field is generated by an electromagnet will be explained below as a third example of implementation of the invention, with reference to figure 3. In this case, only the differentiation characteristics in relation to the first example will be covered in more detail. execution (figure 1), while in relation to the other characteristics - which will not be described in more detail afterwards - express reference is made to the description of the first example of execution. In figure 3, the same or corresponding elements in relation to figure 1 are designated with the same
Petition 870190027151, of 03/21/2019, p. 25/46
23/35 reference number supplemented by the suffix “b”.
[00057] In a pipette 10b of the third execution example, a conductive tube 20b is displacably inserted in piston 24 of the first execution example, a piston 24b, comparable to the first execution example, which is formed of metal magnetizable. Between a piston 24b outer circumference and an inner wall of the conductive tube 20b is a sliding film 38b of a ferrous fluid.
[00058] Contrary to the first execution example, in the third execution example the magnetic field necessary for the movement of piston 24b is not generated by a permanent magnet, but through a set of coils 42 that covers three coils 44-1, 44-2, 44-3, arranged in sequence in the axial direction A of the conductive tube 20b. Each of these coils 44-1, 44-2,44-3 comprises a variety of coils 46, which are coaxially wound with the longitudinal central axis A over the circumference of the conductive tube 20b. The beginning and end of each spiral of all coils 44-1, 44-2,44-3 are coupled in separate current circuits 48-1,48-2, 48-3, with which each coil 44-1 , 44-2,44-3 can be supplied with voltage individually and independently from the other coils., In the execution example, each of the current circuits 48-1, 48-2,483 comprises a voltage source 50, as well as a switch 52 connected in series. The voltage sources 50 can be interconnected, that is, they can be supplied by a common power supply set. [00059] Depending on the switching position of the respective switch 52 of the current circuits 48-1.48-2.48-3, coils 44-1.44-2.44-3 can compose a magnetic field with lines inside fields that extend in parallel to the longitudinal central axis A or the interior of coils 44-1, 44-2,44-3 become field insect., According to the switching position of keys 52, piston 24b will be attracted
Petition 870190027151, of 03/21/2019, p. 26/46
24/35 by the magnetic field of one of the coils 44-1, 44-2,44-3 or by a magnetic field formed by two or three coils 44-1, 44-2,44-3, being pulled in the center of the field magnetic, so that the movement of the piston 24b can be activated in the conductive tube 20b by the keys 52.
[00060] The switches 52 are joined with a control set not shown, which, based on a quantity regulated by a user of the product to be pipetted, activate the current supply for the coils 44-1,44-2 in a controlled manner , 44-3. In a simple command example, coil 44-1 could be switched on (switches 52 of current circuit 48-1 are closed), while the two other coils at 44-2.44-3 are switched off (switch 52 current circuit 48-1 closed), while the two other coils 44-2, 443 are switched off (switch 52 of current circuits 48-2,48-3 open), so that only coil 44-1 generates a magnetic field and piston 24b is pulled onto coil 44-1. To release a quantity of product to be pipetted from the nozzle segment, coil 44-2 could then be switched on, while the first coil 44-1 is switched off at the same time. The piston 24b will then be pulled in the center of the second coil 44-2 and then move the corresponding amount of displacement product, i.e., product to be pipetted, from the conductive tube 20b. Correspondingly, the third coil 44-3 could then be connected and the second coil 44-2 could be switched off.
[00061] Coils 44-1, 44-2,44-3 cannot be turned on and off. For more accurate product dosing, certain current intensities between 0 and a maximum value could be driven to the coils. When for two coils 44-1 / 44-2, ie 44-2 / 44-3. Different current intensities are conducted, so the specialist, based on the relationship of current intensities,
Petition 870190027151, of 03/21/2019, p. 27/46
25/35 will be able to easily calculate the superimposed magnetic field, acting on the piston location, performing a very precise positioning of the piston 24b along the central longitudinal axis A in the conductive tube 20b by adjusting certain current intensities. In this way, an accurate dosage of the product to be pipetted is possible, without changing mechanical action between the control set and the piston 24b. In addition, the currents in the different current circuits 48-1, 48-2,48-3 can be switched with high speed, so that intense dosing dynamism can be achieved.
[00062] Next, with references to figures 4 to 6, a third example of carrying out the invention will be explained. Equal or corresponding elements of the third example of execution, compared to the first example of execution, are complemented with the same reference numbers, supplemented by the suffix “c” and then explained only in relation to their differences from the first example of execution, after which reference is made to the description of the first example of execution.
[00063] A pipette 10c of the third embodiment comprises a cylindrical conductive tube 20c in which a piston 24c is integrated, displaceable. Unlike the first and second design examples, piston 24c in the third design example comprises a permanent magnet body 54, which generates a permanent magnetic field.
[00064] The structure of the permanent magnet body 54 is presented in detail in figures 5a through 5c. It can be seen in figures 5b and 5c that the permanent magnet body 54 has a variety of permanent magnet segments 56-1.562.56-3.56-4.56-5 that are positioned sequentially in this numbering, in the axial direction of the conductor tube 20c. Each of the permanent magnet segments 56-1, ..., 56-5 has a
Petition 870190027151, of 03/21/2019, p. 28/46
26/35 magnetization Mi, ... M5, whose magnetization direction is indicated by an arrow in figure 5b. Correspondingly, the magnetizations M1, M5 of all segments of permanent magnet 56-1 ...., 56-5 of all segments of permanent magnet segments 56-1 ....., 56-5 are axially aligned (in parallel with the longitudinal central axis A), however, the direction of the magnetizations M1 M5 of permanent magnet segments 56-1,, 56-5 reciprocally opposite, so that the magnetizations of each permanent magnet segments a another permanent magnet segment along the axial direction, alternately point in one direction or the other direction. Therefore, eventually in the execution example according to figure 5, M1 points upwards, M2 points downwards, M3 upwards or M4 downwards and M5 upwards.
[00065] In the execution example, all the permanent magnet segments 56-1, ... 56-5 have the same axial length Lm and in the permanent magnet body 54, therefore, the direction of magnetization is modified in axial direction , at distances of Lm.
[00066] The magnetizations M1, ... M5 can also be symbolized by the indication of north poles, that is, south magnetic poles of the different permanent magnet segments 56-1 ... 56-5, as shown in figure 5c. The permanent magnet body 54 will then result by joining the permanent magnet segments 561 56-5 in such a way that adjacent permanent magnet segments 56-1 565 are borderline with their poles of identical designation. In the execution example, the south pole of the permanent magnet segments 56-1 is adjacent to the south pole of the permanent magnet segments 56-2, while the north pole of the permanent magnet segments 56-2 is adjacent to the north pole of the segments permanent magnet 56-3 and so on.
[00067] The permanent magnet body 54 can be produced in a
Petition 870190027151, of 03/21/2019, p. 29/46
27/35 simple, with a variety of individual permanent magnets, corresponding to the permanent magnet segments 56-1 ... 56-5 are joined with their poles of identical designation and, for example, are glued together. In the example of execution according to figures 5a to 5c, the permanent magnet body 54 can thus be formed by the union of five individual permanent magnets.
[00068] A permanent magnet body 54, shaped as described above, has a characteristic magnetic field that changes markedly in axial direction, which is illustrated in figure 6 in a field line presentation. It can be recognized that especially at those points, where the orientation of the Mi M5 magnetization is modified, that is, in the passages between neighboring permanent magnet segments 56-1 ... 56-5, an intense magnetic field appears, sharply in a radial direction , which alternately is projected outward, that is, inward. This strong magnetic field characteristic can be used for the control, that is, precise piston detection, as will be described below.
[00069] Basically, the permanent magnet body 54 could present such a shape that it can be integrated precisely adjusted and with sufficient sealing effect inside the conductive tube 20c, being able to directly act as a piston. Preferably, however, the piston 24c has at least one sealing body 58.59 that is integrated between the permanent magnet body 54 and an inner wall of the conductive tube 20c. In the execution example, two sealing bodies 58,59 are provided, which are positioned in end segments of the permanent magnet body 54, so that they surround the circumferential end segments, as well as the front end faces of the permanent magnet body 54. The sealing bodies 58.59 can, for example, be fitted as rubber caps fitted to the tips of the permanent magnet body 54.
Petition 870190027151, of 03/21/2019, p. 30/46
28/35 [00070] Figure 4 shows a set of coils 42c with a variety of coils 44c, whose spirals encircle the outer wall of the conductive tube 20c in an annular form. Each of the coils 44c can therefore produce, in the corresponding axial position inside the conductive tube 20c, an axially oriented magnetic field, which can change with the piston 24c. By controlling / regulating a current flowing through the coils 44c, through a magnetic coil field changer, then generated as a magnetic field of the permanent magnet body 54 (figure 6), a force can be exerted on the piston 24c in the direction axial conductive tube 20c, to move piston 24c to aspirate or release the medium to be metered.
[00071] The coils 44c have an axial coil I length and are arranged at reciprocal distances. In this case, the distance s can be measured between adjacent coils 44c, conveniently between their axial positions (in I / 2) of each coil 44c.
[00072] The distance s between adjacent coils 44c will preferably be predicted depending on the axial length Lm of the permanent magnet segments 56-1 ... 56-5 ', as well as depending on the phase control of the coils 44c. Corresponding to the arrangement of the permanent magnet segments 561 ... 56-5 with alternating magnetization direction (see figure 5), it is inferred that the magnetic field in axial direction has a period of 2 x Lm. If the piston displacement 24c, covering this extension of the period, can be carried out by sequential activation of a variety of axially sequential coils 44c, so that this can be achieved by an operation of n phases of coils 44c, when the distance between coils neighbors is from
S = 1 / n x 2 Lm.
[00073] According to this equation it would therefore be for a
Petition 870190027151, of 03/21/2019, p. 31/46
29/35 three-phase operation, for example, a distance between coils of s = 2/3 Lm, whereas for a four-phase operation, the distance between coils should be s = 1/2 x Lm.
[00074] For an especially accurate, that is, automatic, dosage of the product, the current flowing through the coils 44c can be regulated depending on a pickup movement or piston position 24c. As shown in figure 4, for this purpose the coils 44c can be joined with a control set 45 that is able to control the current flowing through the coils 44c, that is, the voltage applied to the coils 44c. The control set 45 is part of a regulating circuit and receives a register value from a register element of position 47 which indicates the movement or / and the position of the piston 24c. The position recording element 47 can extend along the conductive tube 20c. In the execution example according to figure 4, the position recorder element 47 is an optical detector, for example, optical line sensor (CCD line sensor, CMOS line sensor or similar unit) from a set of unidimensional photodetectors extending along the conductive tube 20c. The optical record of the position, that is, of the movement of the piston 24c, has the advantage that there is only a reduced or even totally absent interference between the position / movement record and the magnetic control of the piston by the coils 44c.
[00075] In operation, control set 45 is connected to a voltage source 50c, as well as an input unit 52c, via input unit 52c (eg an electronic input unit, especially a computer) , the user can register a desired dosage amount. The registration by the user will be transferred to the command set 45, which calculates from there a theoretical position or theoretical movement, corresponding to the quantity of
Petition 870190027151, of 03/21/2019, p. 32/46
30/35 dosing, for piston 24c. Depending on the register value, indicated by the position register element 47, the control set 45 - during the dosing process - repeatedly determines a deviation between the registered position, that is, the piston movement 24c, and the movement theoretical, ie theoretical position of piston 24c and controls the current intensity of coils 44c depending on the extent of this deviation. The control set 45, in this case, will preferably control the chains of the bonina in such a way that the force effect on the piston 24c becomes more intense the greater the regulation deviation between the movement / position of the registered piston and the movement / theoretical piston position.
[00076] Next, with reference to figure 7, a fourth example of carrying out the invention will be explained. The fourth example of execution can be considered as a variant of the third example of execution, so that, afterwards, only the differences will be addressed and with respect to the elements of the pipette, not rewritten again, express reference will be made to the description of the third example of execution.
[00077] A pipette 10d of the fourth example of execution comprises a conductive tube 20d, in which is integrated, displaceable, a piston not shown. For position control, ie movement of the piston through a magnetic interaction, a set of coils 42d with a variety of coils 44-1d, 44-2d, 44-3d, 44-d on the outer circumference of the pipe is provided conductor 20d. Of the coils, shown in the cutout presentation in figure 7, coils 44-1d and 44-2d are arranged in a first axial position of the conductive tube 20d, while coils 44-3d and 44-4d are arranged in a second position (other) axial position of the conductive tube 20d. preferably other pairs of coils are provided, not shown in figure 7, axially distributed in the conductive tube 20d.
Petition 870190027151, of 03/21/2019, p. 33/46
31/35 [00078] The coil 44-1d which is described representing all coils 44-1d, ..., 44-d, comprises a variety of coils 60d, with each coil 60d having approximately the shape of a rectangle that juxtaposes on the outer cylindrical wall of the conductive tube 20d. Correspondingly, each spiral 60d involves two angular segments 62, projected in a circumferential direction, as well as two segments of axial spirals 64.
[00079] A variety of these 60d spirals of rectangular shape extend reciprocally wrapped, that is, fitted, in a form facing the outer wall of the conductive tube 20d. In addition, spirals of this species may also be arranged in several layers on the outer face of the conductive tube 20d, as shown in figure 7 with reference number 66. The largest number of spirals 60d, immediately arranged on the outer side of the conductive tube 20d and eventually, the additional coils that are arranged in the outer layers 66, preferably are wound on a single continuous wire, on whose ends the current of the coils is fed or eliminated, so that the coil 44-1d generates a magnetic field.
[00080] The axial extension of the axial spiral segments 64 is preferably selected in such a way that the votive segments 62d, interconnected by the axial wall segments 64, and that circumferentially extend, present axially a distance between them, which it can be chosen according to the distance s, described above as described above in connection with the third embodiment of the invention, especially depending on the length Lm of permanent magnet segments of a piston permanent magnet body. Thus, the average axial length s of the coil 44-1d, i.e., the medical axial length of the axial wall segments 64 can be determined, as determined from equation (1) above.
Petition 870190027151, of 03/21/2019, p. 34/46
32/35 [00081] The wall segments 62d that extend circumferentially, in the execution example, are so shaped that they do not involve the outer circumference of the conductive tube 20d completely as a ring, but only extend a circumferential angle less than 360 ° , preferably less than 180 ° (see figures 7 and 10). In the execution example, the circumferential angle, covered by the spiral segments 62d projecting in the circumferential direction, is approximately between 80 and 120 °. In a free circumferential segment 68d, not covered by the coil 44-1d, the conductive tube 20d can offer access from the outside, in order to enable visual control of the dosing process or to arrange a position recording element to be further described, without that it encounters an obstacle in the coil 44-1d.
[00082] When the spiral segments 62 projecting circumferentially over an envelope angle less than 180 °, this means that the coils 60d of the coil 44-1d are arranged entirely on one side of a longitudinal central plane E that contains the central axis longitudinal A of the conductive tube 20d (figure 10). In this way it is possible to arrange a second coil 44-2d, symmetrical with respect to coil 44-1d, in the same axial position as the first coil 44-1d. In the region of the intersection line between the longitudinal central plane AND the outer wall of the conductive tube 20d, the free circumferential segment 68d extends between the coils 44-1d, 44-2d, as well as another opposite free circumferential segment 70d.
[00083] In the execution example, the coils 60d of coils 44-1d and 44-2d, the coils 60d of coils 44-1d and 44-2d are also arranged in such a way that all coils 60d of the two coils 44-1d and 44-2d are essentially located between two tangential planes T1, T2 that are tangentially adjacent on opposite external sides (here in the area of free circumferential segments
Petition 870190027151, of 03/21/2019, p. 35/46
33/35
68d, 70d) of the conductive tube 20d, being parallel to each other. Such an arrangement results in the additional advantage that in the queuing of several conductive tubes 20d, a higher junction density can be achieved than in a pipette, in which the coil spirals completely surround the conductive tube. As can be well recognized in the comparison of figures 9 and 10, in the case of the fourth example of execution, according to figure 10, a width y1 of the coils 441d and 44-2d in an orthogonal direction towards the longitudinal central axis A and parallel to the longitudinal central plane E, is less than a corresponding width y2 of a coil 44c (for example, coil 44c of the third embodiment), which surrounds the conductive tube in an annular form. Especially, in this way, a variety of conductive tube 20d, according to the fourth example of implementation of the invention - which in their free circumferential segments 68d, or 70d are juxtaposed - are joined in such a densified way that coils 44-1d and 44 -2d essentially does not create obstacles to the disposal. A pipette with several conductive tubes 20d can therefore present, at least in one dimension, a more compact constitution.
[00084] Figure 8 presents a fifth example of execution of the invention as a variant of the fourth example of execution of the invention, and the coils 44-1e, 44-2e of a set of coils 42e also do not completely surround a conductive tube 20e of a pipette 10e, to achieve the advantages and facts described in connection with the fourth example of carrying out access to the conductive tube 20e from the outside, as well as a higher joint density of several conductive tubes 20e. [00085] Contrary to the fourth execution example, in the fifth execution example, not all the spiral segments 60e of the coils 44-1e and 44-2e project on the outer wall of the conductive tube 20e or in parallel with the outer wall. Instead, a
Petition 870190027151, of 03/21/2019, p. 36/46
34/35 spiral 60e of the fifth embodiment shows spiral segments 72 extending from the outer wall of the conductive tube 20e in a direction away from the conductive tube 20e, the ends of which are joined again. The axial magnetic field inside the conductive tube 20e generates spiral segments 62e projected in a circumferential direction, the ends of which are joined with the spiral segments 72 that move away from the conductive pipe 20e. As can be seen in figure 8, in the fifth example of execution the spirals 60e, especially, in an essential way, can project in the direction of orthogonal planes in relation to the longitudinal central axis A. [00086] Also in the fifth example of execution, preferably two symmetrical coils 44-1e and 44-2e are applied on both sides of a longitudinal central plane E of the conductive tube 20e so that together they generate a relatively homogeneous and axial magnetic field inside the conductive tube 20e., comparable to the magnetic field of a coil with spirals that surround the conductive tube in an annular shape (for example, according to figure 4).
[00087] In addition, in figure 8, in one of two opposite and free circumferential segments 68e, 70e, whose outer circumference of the conductive tube 20e is not covered by spirals 60e of the coils 441e and 44-2e, a recording element is arranged position 74, especially a magnetic measuring system, which allows an axial recording of a magnetic field generated by a piston inserted in the conductive tube 20e. The position recording element 74 can, for example, be a magnetizable strip that extends axially on the free circumferential segment 68e or / and 70e and whose axial magnetization profile can be read from a magnetic reader unit to register a position / piston movement.
[00088] The movement / position of the piston thus registered will preferably be returned to a command set as a signal
Petition 870190027151, of 03/21/2019, p. 37/46
35/35 regulator, which, based on the regulator signal, provides a command signal, based on which for the coils 44-1e and 44-2e current is conducted with determined intensity. The coils 44-1e and 44-2e, the strainer set, as well as the position recording element 74 will then constitute important components of a closed regulator circuit to adjust the position, that is, the movement of the piston that moves in. of the conductive tube 20e and, therefore, result in automatic, precise regulation of a dosing process of the pipette 10e.
[00089] Also when the free circumferential segments in the fourth and fifth execution examples facilitate the technical effort to assemble and operate a position recording element, it is possible to provide, advantageously, position recording elements or other measures for recording the position , that is, the movement of the piston also in other examples of the invention, especially in the examples described above from 1 to 3. For example, the position register element 74 which projects axially from the fifth example of execution can also be used. used in pipettes, in which the outer coils completely evolve the conductive tube, with approximately a magnetizable strip between the outer wall of the conductive tube and the spirals of the berets being introduced. A corresponding correction of the registration signal of the position recording element will then be necessary based on the magnetic field generated by the coils.
[00090] Other means known to the specialist for recording the position / movement of the piston, for example, an optical record or a record based on other electromagnetic signals or acoustic signals, can also be imagined and accompany the advantage that electromagnetic waves or Acoustics, used to register the position / movement of the piston do not - or only to a lesser extent, interfere with the magnetic field of the coils, that is, the piston.

权利要求:
Claims (15)
[1]
1. Pipette (10c, 10d, 10e), comprising
- a conductive tube (20c, 20d, 20e)
- a piston (24c) which is movable within the conductive tube (20c, 20d, 20e),
- an activation set (42c, 42d, 42e) to exert a force on the piston (24c) in order to move the piston (24c) in the conductive tube (20c, 20d, 20e),
- a chamber (28, 30) for receiving a medium (34) to be dosed, the medium (34) to be dosed can be aspirated or released according to a displacement of the piston (24), the activation set ( 40, 40a, 42, 42c, 42d, 42e) is configured for a magnetic interaction with the piston (24, 24a, 24b, 24c) and features a magnetic field generator set to generate a magnetic field, and the pipette ( 10, 10a, 10b, 10c, 10d, 10e) comprises a control set to control the extension or / and position or / and direction of the magnetic field, characterized by the fact that the piston (24c) has a permanent magnet (54) , the pipette comprising a position detector (74), which provides a register value that indicates the movement or position of the piston (24, 24a, 24b, 24c) for regulating the position of the piston and the control set is configured to adjust the piston position by returning the register value indicating the movement or position of the piston (2 4, 24a, 24b, 24c).
[2]
2. Pipette (10c, 10d, 10e) according to claim 1, characterized by the fact that the magnetic field generator set (42c, 42d, 42e) is configured to generate a magnetic field whose magnetic flux passes through the piston (24c ) essentially axially towards the conductive tube (20c, 20d,
Petition 870190027151, of 03/21/2019, p. 39/46
2/4
20e).
[3]
3. Pipette (10c, 10d, 10e) according to claim 1 or 2, characterized by the fact that the activation set (42c, 42d, 42e) is configured to generate a moving magnetic field essentially in axial direction (A) the conductive tube (20c, 20d, 20e).
[4]
4. Pipette (10c, 10d, 10e) according to any of the preceding claims, characterized by the fact that the magnetic field generator set comprises a permanent annular magnet, which coaxially surrounds the conductive tube.
[5]
5. Pipette (10c) according to any one of the preceding claims, characterized by the fact that the magnetic field generator set (42c) comprises a set of coils with at least one coil (44c), whose spirals coaxially surround the conductive tube (20c).
[6]
Pipette (10c) according to any one of the preceding claims, characterized in that the magnetic field generator set (42c) comprises a set of coils with a plurality of coils (44c) whose spirals coaxially surround the conductive tube ( 20c), the coils (44c) being axially offset from one another.
[7]
7. Pipette (10d, 10e) according to any one of the preceding claims, characterized in that the magnetic field generator set comprises a coil set with at least one coil (44-1d, 44-2d, 44-1e , 44-2e), presenting at least one spiral (60d, 60e), with the at least one spiral (60d, 60e) involving only a partial segment of the circumference of the conductive tube (20d, 20e).
[8]
8. Pipette (10d, 10e) according to any of the preceding claims, characterized by the fact that the set
Petition 870190027151, of 03/21/2019, p. 40/46
3/4 magnetic field generator comprises a set of coils with at least one coil (44-1d, 44-2d, 44-1e, 44-2e), which has at least one spiral (60d, 60e), the at least one spiral (60d, 60e) extends entirely on one side of a central longitudinal plane (E) that contains a central longitudinal axis (A) of the conductive tube (20d, 20e).
[9]
9. Pipette (10d, 10e) according to claim 7 or 8, characterized in that the at least one spiral (60d, 60e) extends completely between two tangential planes (T1, T2) of the conductive tube (20d, 20e) which are reciprocally parallel, which contact the outer wall of the conductive tube (20d, 20e).
[10]
10. Pipette (10d, 10e) according to claim 8 or 9, characterized in that the coil arrangement (42d, 42e) comprises a first coil (44-1d, 44-1e) with at least one first coil and a second coil (44-2d, 44-2e) with at least one second spiral, the at least one first spiral extending entirely on one side of the longitudinal central plane (E) and the at least one second spiral extending totally on the other side of the central longitudinal plane (E).
[11]
11. Pipette (10d, 10e) according to any of claims 7 to 10, characterized in that the at least one spiral (60d, 60e) has a segment of spirals (62d, 62e) extending in a circumferential direction along an outer wall of the conductive tube (20d, 20e).
[12]
Pipette (10d) according to any one of claims 7 to 11, characterized in that the at least one spiral (60d) has a spiral segment (64) that projects axially along an external wall of the tube conductor (20d).
[13]
13. Pipette (10e) according to any of the
Petition 870190027151, of 03/21/2019, p. 41/46
4/4 claims 7 to 12, characterized by the fact that the at least one spiral (60e) has a spiral segment (72) that extends in the direction of the conductive tube (20e), and then extends along of the conductive tube (20e) and then extends in the direction away from the conductive tube (20e).
[14]
14. Pipette (10e) according to any one of claims 7 to 13, characterized in that in a partial segment (68e, 70e) of the circumference of the conductive tube (20e), not surrounded by at least one spiral (60e) a position recorder element (74) of a position detector is arranged, the position detector by means of the position recorder element (74) records a register value indicating the movement or position of the piston.
[15]
15. Pipette (10e) according to claim 14, characterized by the fact that the position recording element (74) is configured for a magnetic interaction with the piston.

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JPH06303755A|1994-10-28|Linear motor

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SU1636776A1|1991-03-23|Magnetoelectric measuring mechanism

同族专利:

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公开号 | 公开日

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DE102010000690A1|2011-07-07|

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BR112012016438A2|2017-03-07|

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CN102892507B|2016-01-13|

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ES2609431T3|2017-04-20|

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EP2521620A1|2012-11-14|

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ES2640464T3|2017-11-03|

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WO2011083125A1|2011-07-14|

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CN102892507A|2013-01-23|

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EP2656917B1|2017-06-21|

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US9186666B2|2015-11-17|

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EP2521620B1|2016-10-12|

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JP2013516618A|2013-05-13|

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US20130001242A1|2013-01-03|

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EP2656917A1|2013-10-30|

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JP5926192B2|2016-05-25|

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法律状态:
2018-04-10| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2019-01-29| B06T| Formal requirements before examination [chapter 6.20 patent gazette]|

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2019-10-22| B07A| Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]|

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2020-03-03| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2020-05-05| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/01/2011, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

---

DE102010000690A|DE102010000690A1|2010-01-05|2010-01-05|Dosing device and dosing process|

---

PCT/EP2011/050105|WO2011083125A1|2010-01-05|2011-01-05|Metering device and metering method|

---